A lower but nonsignificant AMD risk was observed in those with brown compared to blue iris color.Īll images were independently graded by the Network of Ophthalmic Reading Centres UK (NetwORC UK) in Belfast. Retinal vascular caliber was not significantly associated with iris color or early/late AMD after adjustment for confounders. A nonsignificant reduced risk of any AMD or late AMD only was observed in association with brown compared to blue iris color, in both unadjusted and adjusted analyses. ![]() Individuals with any AMD (early or late AMD) had significantly narrower arterioles and venules compared to those with no AMD in an unadjusted analysis, but this was no longer significant after adjustment. Age-related macular degeneration status was categorized as no AMD, any AMD, and late AMD only. In an unadjusted analysis, we found some support for a previous finding that individuals with blue iris color had narrower retinal venules compared to those with brown iris color ( P < 0.05), but this was no longer significant after adjustment. In total, 1122 (91%) participants had gradable retinal images of sufficient quality for vessel assessment (mean age: 76.3 years ). ![]() Regression models were used to assess associations, adjusting for age, mean arterial blood pressure, body mass index, refraction, and fellow RVC. Macular images were graded according to the modified Wisconsin Age-related Maculopathy Grading System. To evaluate the relationship between retinal vascular caliber (RVC), iris color, and age-related macular degeneration (AMD) in elderly Irish nuns.ĭata from 1233 participants in the cross-sectional observational Irish Nun Eye Study were assessed from digital photographs with a standardized protocol using computer-assisted software.
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